Nelfinavir in mix with other antiretroviral agents is shown for the treatment of HIV-1 disease.
Measurement AND ADMINISTRATION
Grown-ups And Adolescents (13 Years and Older)
The suggested portion is 1250 mg (five 250 mg tablets or two 625 mg tablets) twice day by day or 750 mg (three 250 mg tablets) multiple times day by day. VIRACEPT ought to be taken with a dinner. Patients incapable to swallow the 250 or 625 mg tablets may break up the tablets in a modest quantity of water [see Method of Administration].
Pediatric Patients (2 to Less than 13 Years)
In kids 2 years old and more established, the suggested oral portion of VIRACEPT Oral Powder or 250 mg tablets is 45 to 55 mg/kg twice day by day or 25 to 35 mg/kg multiple times day by day. All portions ought to be taken with a feast. Dosages higher than the grown-up greatest portion of 2500 mg each day have not been concentrated in kids.
For youngsters unfit to swallow tablets, VIRACEPT 250 mg tablet(s) might be broken down in a limited quantity of water or, VIRACEPT Oral Powder might be regulated [see Method of Administration].
The medical services supplier ought to survey fitting detailing and dose for every tolerant. Tables 1 and 2 give dosing rules to VIRACEPT tablets and powder dependent on age and body weight.
VIRACEPT® (nelfinavir mesylate) is an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease. VIRACEPT Tablets are accessible for oral organization as a light-blue, case molded tablet with an unmistakable film covering in 250 mg strength (as nelfinavirfree base) and as a white oval tablet with a reasonable film covering in 625 mg strength (as without nelfinavir base). Every tablet contains the accompanying regular latent fixings: calcium silicate, crospovidone, magnesium stearate, hypromellose, and triacetin. Moreover, the 250 mg tablet contains FD&C blue #2 powder and the 625 mg tablet contains colloidal silicon dioxide. VIRACEPT Oral Powder is accessible for oral organization in a 50 mg/g strength (as sans nelfinavir base) in bottles. The oral powder likewise contains the accompanying dormant fixings: microcrystalline cellulose, maltodextrin, dibasic potassium phosphate, crospovidone, hypromellose, aspartame, sucrose palmitate, and normal and fake flavor. The substance name for nelfinavir mesylate is [3S-[2(2S*, 3S*), 3α,4aβ,8aβ]]-N-(1,1-dimethylethyl)decahydro-2-[2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinoline carboxamide mono-methanesulfonate (salt) and the sub-atomic weight is 663.90 (567.79 as the free base). Nelfinavir mesylate has the accompanying primary recipe:
Nelfinavir mesylate is a white to grayish shapeless powder, marginally dissolvable in water at pH ≤ 4 and openly solvent in methanol, ethanol, 2-propanol and propylene glycol.